Thionyl Chloride → HCID 13676766, compound

Participants

Reaction Steps

14 Parts of sulfinyl chloride are stirred and there is added dropwise a solution of 37 parts of N-[1-(2-hydroxypropyl)-4-(methoxymethyl)-4-piperidinyl]-N-phenylpropanamide monohydrochloride in 360 parts of dichloromethane. Upon completion, stirring is continued overnight at reflux temperature. The reaction mixture is evaporated and the residue is suspended in 2-propanone. The product is filtered off and dried, yielding 31.5 parts (85%) of N-[1-(2-chloropropyl)-4-(methoxymethyl)-4-piperidinyl]-N-phenylpropanamide monohydrochloride.

Provenance & Evidence