HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxy-2-nitroaniline → HCID 178493297, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxy-2-nitroaniline | HCID 66793 | — |
| Reactant | Ethyl 4,4,4-trifluoroacetoacetate | HCID 67793 | — |
| Product | HCID 178493297 | HCID 178493297 | 27% |
Reaction Steps
The reaction of 4-methoxy-2-nitroaniline with ethyl trifluoroacetoacetate in polyphosphoric acid at 130°-140° gave 4-hydroxy-6-methoxy-8-nitro-2-trifluoromethylquinoline. The pure compound (tan crystals, mp 138°-140° ) was obtained in 27% yield following several crystallizations of the crude product from ligroin.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04167638 |
| Source dataset | uspto-grants-1979_09 |
| ORD ID | ord-5253d612d88a4a53be0e4e6c1c20af15 |
| Source note | uspto-grants-1979_09 |