HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methyl-5,6-dimethoxy-8-nitroquinoline → 8-Amino-5,6-dimethoxy-4-methylquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methyl-5,6-dimethoxy-8-nitroquinoline | HCID 619108 | — |
| Catalyst | Nickel | HCID 935 | — |
| Product | 8-Amino-5,6-dimethoxy-4-methylquinoline | HCID 609009 | 84% |
Reaction Steps
The nitro compound was reduced catalytically in ethanol-dioxane with use of Raney nickel. An 84% yield of 8-amino-5,6-dimethoxy-4-methylquinoline resulted. It could be crystallized from cyclohexane or from benzene-petroleum ether mixture; mp 108°-110° (softening at 103°).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04167638 |
| Source dataset | uspto-grants-1979_09 |
| ORD ID | ord-ebead29cebfc45149c8d577afa90c8bc |
| Source note | uspto-grants-1979_09 |