Methyl vinyl ketone → HCID 20393396, compound

HRID 1863121Notes

Reaction equation

HRID 1863121 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1.[CH:12]([C:14]([CH3:16])=O)=[CH2:13]>>[F:1][C:2]1[CH:8]=[C:7]2[C:5](=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1)[N:6]=[CH:13][CH:12]=[C:14]2[CH3:16]

Participants

3

Reactant 2

HCID 6570Methyl vinyl ketoneHCID 677694-Fluoro-2-nitroaniline

Product 1

HCID 20393396HCID 20393396, compoundYield 39%

Procedure

A Skraup reaction was run with 4-fluoro-2-nitroaniline and methyl vinyl ketone. The crude product was recrystallized multiply from benzene to obtain a 39% yield of pure 6-fluoro-4-methyl-8-nitroquinoline; mp 139°-141°.

Workup

  1. customA Skraup reaction
  2. customThe crude product was recrystallized multiply from benzene

Sources & evidence

ORD record
ord-510bc871c3424ca09015cb8346398756
Source dataset
uspto-grants-1979_09
Patent number
US04167638

Reaction notes

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