Diethyl Ether → HCID 70601464, compound

HRID 1863129Notes

Reaction equation

HRID 1863129 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:18][CH3:19])=[C:6]([C:8]2[N:16]=[C:15]3[C:11](=[N:12][N:13]=[N:14]3)[C:10](=[O:17])[N:9]=2)[CH:7]=1.C(OCC)C.[C:25]([CH2:28][C:29](=O)[CH3:30])(=[O:27])[CH3:26]>>[C:25]([CH:28]=[C:29]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([O:18][CH3:19])=[C:6]([C:8]2[N:16]=[C:15]3[C:11](=[N:12][N:13]=[N:14]3)[C:10](=[O:17])[N:9]=2)[CH:7]=1)[CH3:30])(=[O:27])[CH3:26]

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 31261AcetylacetoneHCID 20392978HCID 20392978, compound

Product 1

HCID 70601464HCID 70601464, compound

Procedure

A stirred suspension of 2-(5-amino-2-methoxyphenyl)-8-azapurin-6-one (1.34 g) in acetylacetone (15 ml) was heated at reflux for one hour. The mixture was then cooled and poured into diethyl ether (100 ml). The precipitated solid was filtered off and recrystallised twice from ethanol with the aid of charcoal to give 2-[5-(1-acetylprop-1-en-2-ylamino)-2-methoxyphenyl]-8-azapurin-6-one (1.2 g), m.p. 239°-240° C. (with decomposition).

Workup

  1. temperaturewas heated
  2. temperatureat reflux for one hour
  3. temperatureThe mixture was then cooled
  4. filtrationThe precipitated solid was filtered off
  5. customrecrystallised twice from ethanol with the aid of charcoal

Sources & evidence

ORD record
ord-74014326d6e94ba4b9b282d00fb758bb
Source dataset
uspto-grants-1979_09
Patent number
US04167568

Reaction notes

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