Ammonia → HCID 20392396, compound

HRID 1863213Notes

Reaction equation

HRID 1863213 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([O:10][CH2:11][CH:12]3[O:14][CH2:13]3)[C:4]=2[CH:3]=[N:2]1.[NH3:15]>C(O)C>[OH:14][CH:12]([CH2:13][NH2:15])[CH2:11][O:10][C:9]1[C:4]2[CH:3]=[N:2][S:1][C:5]=2[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 128988131-(1,2-Benzisothiazol-4-yloxy)-2,3-epoxy-propane

Product 1

HCID 20392396HCID 20392396, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4.0 g of 1-(1,2-benzisothiazol-4-yloxy)-2,3-epoxy-propane in 100 ml of aqueous ammonia and 300 ml of ethanol are left to stand for 3 hours at 35° C. The mixture is concentrated, the semi-crystalline residue is dissolved in ethanol and a solution of hydrogen chloride in ether is added dropwise. The hydrochloride which precipitates is filtered off, washed with dry ether and dried.

Workup

  1. concentrationThe mixture is concentrated
  2. dissolutionthe semi-crystalline residue is dissolved in ethanol
  3. additiona solution of hydrogen chloride in ether is added dropwise
  4. customThe hydrochloride which precipitates
  5. filtrationis filtered off
  6. washwashed with dry ether
  7. customdried

Sources & evidence

ORD record
ord-652721a751a74a808db260791d0a5390
Source dataset
uspto-grants-1979_09
Patent number
US04168317

Reaction notes

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