Formic Acid → HCID 20392480, compound

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Reaction Steps

A solution of 20 g of crude 2-methyl-4,5-di-(chloromethyl)-6-benzyl-pyridin-3-ol in 40 g of 75% strength formic acid is heated under reflux. After 10 minutes, a solution of 10.7 g of sodium hydroxide in 15 ml of water is added and heating is continued for 1 hour. The mixture is concentrated to dryness under reduced pressure. The residue is digested in 100 ml of acetone, the insoluble constituent is filtered off, the filtrate is concentrated and the residue thus obtained is boiled for 1/2 hour in 50 ml of water. After again concentrating the mixture, the residue is recrystallized from acetone. 5.7 g of 2-methyl-4,5-di-(hydroxymethyl)-6-benzyl-pyridin-3-ol, of melting point 158°-159° C., are obtained.

Provenance & Evidence