HCID 12708700, compound → HCID 20392478, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 19.4 g (0.1 mole) of 2-methylsulfonyl-1,4-dimethoxy-but-2-ene and 34.6 g (0.2 mole) of 2-benzyl-4-methyloxazole is heated for 10 hours at 190° C. After it has cooled, unconverted oxazole and sulfone are distilled off in a high vacuum. The residue is chromatographed over silica gel (using ethyl acetate and methanol). 5.5 g of 2-methyl-4,5-di-(methoxymethyl)-6-benzyl-pyridin-3-ol, identified by the NMR spectrum, are obtained.

Provenance & Evidence