cis-4,7-Dihydro-1,3-dioxepin → HCID 20392512, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 8.4 g (40 millimoles) of 2-benzyl-4-methyl-5-ethoxyoxazole and 20 g (200 millimoles) of 4,7-dihydro-1,3-dioxepine is heated for 4 hours at 180° C. in an autoclave. Unconverted 4,7-dihydro-1,3-dioxepine is distilled off under reduced pressure. The residue is taken up in methylene chloride and extracted with 10% strength sodium hydroxide solution. On neutralizing the alkaline solution, 5.2 g of 6-benzyl-8-methyl-1,5-dihydro-[1,3]dioxepino[5,6-c]pyridin-9-ol precipitate and these are extracted with methylene chloride.

Provenance & Evidence