Sodium Hydroxide → HCID 20392487, compound

HRID 1863253Notes

Reaction equation

HRID 1863253 reaction equation
[CH2:1]([C:8]1[O:9][CH:10]=[C:11]([C:13]([O:15]CC)=[O:14])[N:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[CH2:1]([C:8]1[O:9][CH:10]=[C:11]([C:13]([OH:15])=[O:14])[N:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 20392522HCID 20392522, compound

Product 1

HCID 20392487HCID 20392487, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Hydrolysis of this ester with a solution of sodium hydroxide in methanol at 15° C. gives 20.5 of 2-benzyl-oxazole-4-carboxylic acid, melting point 155°-156° C., which, when decarboxylated with copper powder at 210°-220° C., gives 12.5 g of 2-benzyloxazole, boiling point 134°-136°/25 mm Hg; nD25 1.5395.

Sources & evidence

ORD record
ord-4a70938c0c5d47ab8b34d1f5b0de35d4
Source dataset
uspto-grants-1979_09
Patent number
US04168379

Reaction notes

Loading…