HCID 5323667, compound → 1,3-Dihydro-4-(phenylmethyl)furo[3,4-c]pyridin-7-ol

Participants

Reaction Steps

11.2 g (70 millimoles) of 2-benzyloxazole and 10.5 g (70 millimoles) of 3-methylsulfonyl-2,5-dihydrofuran are heated for 7 hours at 160°. The unconverted starting compounds are distilled off in a high vacuum and the distillation residue is extracted with methylene chloride. The 4-benzyl-1,3-dihydro-furo[3,4-c]pyridin-7-ol contained in the extract is separated off by chromatography over silica gel (using methylene chloride and ethyl acetate). 4.3 g are obtained. Recrystallization from benzene/methylene chloride gives a pure product.

Provenance & Evidence