HCID 12543456, compound → HCID 20336525, compound

Participants

Reaction Steps

9.4 g (50 millimoles) of 2-benzyl-4-ethyloxazole and 29.6 g. (200 millimoles) of 3-methylsulfonyl-2,5-dihydrofuran are heated for 15 hours at 150°. Unconverted sulfone is distilled off in a high vacuum. The residue is digested in methylene chloride, the undissolved constituent is filtered off, and the filtrate is extracted with 150 ml of 10% strength sodium hydroxide solution. The alkaline solution is neutralized and extracted with methylene chloride. On concentrating the methylene chloride solution, 6.2 g of 4-benzyl-6-ethyl-1,3-dihydro-furo[3,4-c]pyridine-7-ol remain. Melting point, after recrystallization from nitromethane: 148° C.

Provenance & Evidence