Potassium Carbonate → HCID 85901699, compound

Participants

Reaction Conditions

Reaction Steps

A slurry of 3.45 g of anhydrous potassium carbonate in 50 ml of hexamethylphosphoramide (HMPA) containing 6.8 g of ethyl[p-(p-aminophenoxy)phenyl]acetate is heated to 50° C. A solution of 6 g of n-octyliodide in 10 ml of HMPA is added over 2 hours. The heating is continued for 24 hours. The mixture is diluted with 100 ml of H2O and extracted with two 100 ml portions of ether. The combined extracts are washed with two 100 ml portions of H2O, 100 ml of saturated brine, and dried over MgSO4. Evaporation of the solvent at reduced pressure affords a brown liquid, which yields, after silica gel chromatography (benzene, then CHCl3) and bulb-to-bulb distillation of the CHCl3 eluate, a pale yellow oil, b.p. 194° @ 0.05 mm.

Provenance & Evidence