3-Phenylphenol → HCID 12531849, compound

HRID 1863298Notes

Reaction equation

HRID 1863298 reaction equation
Br[CH:2]([C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)=[CH:9][CH:8]=1)[C:3]([O:5][CH3:6])=[O:4].[C:21]1([C:27]2[CH:28]=[C:29]([OH:33])[CH:30]=[CH:31][CH:32]=2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>CO>[C:27]1([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:32]=[CH:31][CH:30]=[C:29]([O:33][CH:2]([C:7]2[CH:12]=[CH:11][C:10]([O:13][C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=3)=[CH:9][CH:8]=2)[C:3]([O:5][CH3:6])=[O:4])[CH:28]=1

Participants

4

Reactant 2

HCID 113813-PhenylphenolHCID 20392594Methyl alpha-Bromo-alpha-[p-(p-chlorophenoxy)phenyl]acetate

Product 1

HCID 12531849HCID 12531849, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner as in Example 39, 7.11 g of methyl α-bromo-α-[p-(p-chlorophenoxy)phenyl]acetate is reacted with 4.25 g of 3-phenylphenol in methanol to give a yellow oil, which is subjected to fractional bulb-to-bulb distillation (175°-178° C. @ 0.02 mm) to remove volatile impurities. The glassy residue is subjected to filtration through 200 g of silica gel (benzene) and concentration to yield the product as an orange foam.

Workup

  1. customto give a yellow oil, which
  2. distillationis subjected to fractional bulb-to-bulb distillation (175°-178° C. @ 0.02 mm)
  3. customto remove volatile impurities
  4. filtrationThe glassy residue is subjected to filtration through 200 g of silica gel (benzene) and concentration

Sources & evidence

ORD record
ord-099457ace7304eb680d31b384b6071d2
Source dataset
uspto-grants-1979_09
Patent number
US04168385

Reaction notes

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