Methanol → racemic (2'S,3S,4'R)-6-chloro-2'-(3-chlorophenyl)-4'-(4-chlorophenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

HRID 186337Notes

Reaction equation

HRID 186337 reaction equation
[CH2:1]([O:2][C:3](=[O:4])[N:6]1[C:7](=[O:36])[C:8]2([c:9]3[cH:10][cH:11][c:12]([Cl:15])[cH:13][c:14]31)[CH:16]([c:29]1[cH:30][c:31]([Cl:35])[cH:32][cH:33][cH:34]1)[NH:17][C:18](=[O:28])[CH2:19][CH:20]2[c:21]1[cH:22][cH:23][c:24]([Cl:27])[cH:25][cH:26]1)[CH3:5].[CH3:39][OH:40].[Na+:38].[OH-:37]>>[NH:6]1[C:7](=[O:36])[C:8]2([c:9]3[cH:10][cH:11][c:12]([Cl:15])[cH:13][c:14]31)[CH:16]([c:29]1[cH:30][c:31]([Cl:35])[cH:32][cH:33][cH:34]1)[NH:17][C:18](=[O:28])[CH2:19][CH:20]2[c:21]1[cH:22][cH:23][c:24]([Cl:27])[cH:25][cH:26]1

Participants

5

Reactant 4

HCID 887MethanolHCID 923Sodium ionHCID 961HydroxideHCID 76567914racemic (2'S,3S,4'R)-6-chloro-2'-(3-chlorophenyl)-4'-(4-chlorophenyl)-2,3-dihydro-2,6'-dioxo spiro[indole-3,3'-piperidine]-1-carboxylic acid ethyl ester

Product 1

HCID 131727311racemic (2'S,3S,4'R)-6-chloro-2'-(3-chlorophenyl)-4'-(4-chlorophenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

Sources & evidence

ORD record
ord-d4b3dd80f6004819994a082e6601db5b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

Loading…