Nitric Acid → 2-(1,1-Dimethylethyl)-4-methyl-1H-imidazole-5-carboxaldehyde

HRID 1863379Notes

Reaction equation

HRID 1863379 reaction equation
[C:1]([C:5]1[NH:6][C:7]([CH3:12])=[C:8]([CH2:10][OH:11])[N:9]=1)([CH3:4])([CH3:3])[CH3:2].[N+]([O-])(O)=O>>[C:1]([C:5]1[NH:6][C:7]([CH3:12])=[C:8]([CH:10]=[O:11])[N:9]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 944Nitric AcidHCID 12493281HCID 12493281, compound

Product 1

HCID 124932852-(1,1-Dimethylethyl)-4-methyl-1H-imidazole-5-carboxaldehyde

Procedure

A 19.76 gm. portion of 2-tert-butyl-5-methyl-4-imidazolemethanol and 16.5 ml. of concentrated HNO3 are reacted as described in Example 25 giving the desired product, m.p. 196°-198° C.

Sources & evidence

ORD record
ord-8d2f4f34bc2e4241b422b88aa1bcbcf3
Source dataset
uspto-grants-1979_09
Patent number
US04168964

Reaction notes

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