HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 18634Generated: October 26, 2026
Lawesson's reagent → 4-Thiocarbamoylphenyl 2-(4-isobutylphenyl)propanoate
https://huagongshe.com/reaction/18634
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | 4-(5-thioxo-5H-1,2-dithiol-3-yl)phenyl 2-(2-methoxynaphthalen-6-yl)propanoate | HCID 25065986 | — |
| Reactant | 4-Carbamoylphenyl 2-(4-isobutylphenyl)propanoate | HCID 59345589 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 4-Thiocarbamoylphenyl 2-(4-isobutylphenyl)propanoate | HCID 25065768 | 55% |
Reaction Steps
4-carbamoylphenyl 2-(4-isobutylphenyl)propanoate, 3 (2.48 g, 7.62 mmol) and Lawesson reagent (3.1 g, 7.62 mmol) were dissolved in 130 ml of anhydrous benzene. The reaction was warmed to 60° C. and stirred for 4 h. The solvent was removed under reduced pressure. The obtained compound was purified by a silica gel open column and eluted with CH2Cl2/MeOH (9.5/0.5) giving the pure compound 4 (1.45 g, 55% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07741359B2 |
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| Source dataset | uspto-grants-2010_06 |
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| ORD ID | ord-5f52b93a31fb4e17a8175ed2b25290f5 |
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| Source note | uspto-grants-2010_06 |
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