Nitric Acid → HCID 20291401, compound

HRID 1863421Notes

Reaction equation

HRID 1863421 reaction equation
[CH3:1][C:2]1[NH:6][C:5]([C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:16][OH:17].[N+]([O-])(O)=O>O>[CH3:1][C:2]1[NH:6][C:5]([C:7]2[CH:8]=[CH:9][C:10]([N+:13]([O-:15])=[O:14])=[CH:11][CH:12]=2)=[N:4][C:3]=1[CH:16]=[O:17]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 20291409HCID 20291409, compound

Product 1

HCID 20291401HCID 20291401, compoundYield 91.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of 5-methyl-2-(p-nitrophenyl)-4-imidazolemethanol (2.9 gm., 0.012 mole) and 70% nitric acid (20 ml.) is stirred at 50° C. for 3 hours, followed by dilution with water and neutralization with base. The precipitated yellow solid is collected by filtration to yield 2.4 gm. (0.011 mole) of title product, dec. >270° C.

Workup

  1. filtrationThe precipitated yellow solid is collected by filtration
  2. customto yield 2.4 gm

Sources & evidence

ORD record
ord-4ae51f231f954268abaca2a6fdd152e8
Source dataset
uspto-grants-1979_09
Patent number
US04168964

Reaction notes

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