HCID 178418573, compound → HCID 178467221, compound

Participants

Reaction Conditions

Reaction Steps

Methyl magnesium bromide (15.3 ml., 2.5 molar in ether) is added dropwise to a solution of 2-phenyl-4-imidazolecarboxaldehyde (3.0 gm. 0.017 mole) in dry tetrahydrofuran (45 ml.; dried over a molecular sieve) while the temperature of the reaction mixture is maintained with cooling at 25° C. The mixture is stirred for 2 hours, and then decomposed by adding a large volume of water dropwise. The mixture is extracted with ether (3×75 ml.), the ethereal extract is partially evaporated to yield a white precipitate, the crystalline alcohol, m.p. 197°-198° C.

Provenance & Evidence