Acetic Acid → HCID 20291421, compound

Participants

Reaction Steps

Sodium cyanoborohydride (1.2 gm., 0.019 mole) is added to a stirred solution of 8-bromo-6-(m-aminophenyl)imidazo-[1,5-d]-as-triazine-4(3H)-one, aqueous formaldehyde (5 ml., 37%) in acetonitrile (110 ml.). The reaction mixture is stirred for 15 minutes then acetic acid is added to adjust the pH of the reaction mixture to 7. The reaction mixture is stirred for 45 minutes while the pH of the mixture is maintained at 7 with acetic acid being added as needed. The solvent is then evaporated in vacuo, the residual oil is added to 2 N potassium hydroxide (150 ml.), and crystallizes. The product is washed with water, and recrystallized from acetone-water, m.p. 206° C.(d).

Provenance & Evidence