Diphenyl Ether → HCID 20391367, compound

Participants

Reaction Steps

3-{[5-Methyl-2-(α,α,α-trifluoro-m-tolyl)-4-imidazolyl]-methylene}carbazic acid methyl ester (3.0 g) is added rapidly to diphenyl ether (50 ml) preheated to 297° C., and the mixture is then kept at 297° for 15 minutes. The mixture is rapidly cooled to room temperature, hexane (50 ml) is added and the mixture filtered to yield 4.2 g yellow solid. This material is chromatographed on a silica gel column using a hexane-ethyl acetate mixture as eluent. The fractions found to be identical by TLC are combined to afford 1.86 g of the title product, m.p. 194°-194.5° C.

Provenance & Evidence