Water → HCID 54445525, compound

Participants

Reaction Steps

A 42 g (0.22 mole) portion of 6-methoxy-4-chromanone oxime in 600 ml of benzene was refluxed until all water was removed via a Dean-Stark trap. The solution was treated with 1 ml of triethylamine, followed by the dropwise addition of 14 g (0.20 mole) of ethyl isocyanate at reflux. The reaction mixture was refluxed for 4 hrs., stored overnight at room temperature, and stripped of benzene under reduced pressure. The viscous residue was taken up in 250 ml of ether, refrigerated 6 hrs., and filtered. The cream colored solid was washed with 150 ml of ether and dried, m.p. 97°-98°. Yield: 44 g (83%).

Provenance & Evidence