2,4,5-Trichlorophenol → t-Butoxycarbonylglycine-2,4,5-Trichlorophenyl Ester

Participants

Reaction Steps

Prepare and chill a solution of 14 g. of t-butoxycarbonylglycine and 15.8 g. of 2,4,5-trichlorophenol in 200 ml. of ethyl acetate. Add with stirring 18.2 g. of dicyclohexylcarbodiimide in small portions. Stir the reaction mixture at room temperature for 16 hours, filter and evaporate the filtrate to a residue. Wash the residue by triturating with hexane, then crystallize from ethyl ether to obtain thereby the title product (m.p. 100°-103° C.).

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