1-Propanol → HCID 20392015, compound

Participants

Reaction Steps

A solution of 117.0 g of 2-(4-pyridinyl)benzoxazole and 95.0 g of benzyl chloride in 1 liter of a 9:1 mixture of n-propanol and dimethylsulfoxide is heated at reflux for 72 hours. The solvent mixture is then removed and the residue suspended in 100 ml of water. The crystalline product which separates is filtered, washed with acetone, and dried to give 76.6 g of product. Concentration of the mother liquors gives an additional 27.8 g of product, melting point 194°-196° C., dec. Recrystallization from water and drying in a vacuum at 100° C. for 5 hours raises the melting point to 216°-217° C., dec.

Provenance & Evidence