Hydrochloric Acid → HCID 7146200, compound

Participants

Reaction Steps

A solution of 2.41 g (7.5 mmol) of (R)-N-(tert-butoxycarbonyl)-2,4,5-trifluorophenylalanine methyl ester in approximately 200 mL of a mixture of tetrahydrofuran:methanol: 1N lithium hydroxide (3:1:1) was stirred at 50° C. for 4 h. The reaction was cooled, acidified with 5% hydrochloric acid (aqueous) and extracted with ethyl acetate. The combined organic phases were washed with brine, dried over magnesium sulfate and concentrated in vacuo to give the title compound. LC-MS 220.9 (M+1-BOC).

Provenance & Evidence