Sodium periodate → HCID 68524098, compound

Participants

Reaction Steps

To a mixture of 51 mg (0.328 mmol) of ruthenium dioxide and 25.9 mL (11.9 mmol) of 10% sodium periodate aqueous solution was added a solution of 766 mg (2.53 mmol) of tert-butyl 2-(trifluoromethyl)-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxylate in 20 mL of ethyl acetate. The mixture was stirred vigorously for 4 h and then partitioned between ethyl acetate and water. The aqueous phase was extracted with 2 additional portions of ethyl acetate. The combined organic fractions were concentrated. Flash chromatography of the residue on silica gel (9:1 hexanes/ethyl acetate) afforded material that was collected on a filter and washed with diethyl ether to give the title compound as a white solid. LC-MS 318 (M+1).

Provenance & Evidence