反应详情

A solution of 500 mg (2.66 mmol) of 2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrazine (Intermediate 7, Step C) in 2.5 mL of dry ethanol, stirred at 0° C. under protection from moisture, was treated dropwise with 0.151 mL (2.92 mmol) of bromine. After 20 minutes at 0° C., the solution was concentrated and dried to give the title compound as an orange solid. LC-MS 267, 269 (M+1).

1. concentrationthe solution was concentrated
2. customdried