Bromine → HCID 86614846, compound

HRID 1863935Notes

Reaction equation

HRID 1863935 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[N:11]=[C:6]2[CH:7]=[N:8][CH:9]=[CH:10][N:5]2[N:4]=1.[Br:14]Br>C(O)C>[BrH:14].[Br:14][C:10]1[N:5]2[N:4]=[C:3]([C:2]([F:12])([F:1])[F:13])[N:11]=[C:6]2[CH:7]=[N:8][CH:9]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 533933572-(Trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrazine2×

Product 1

HCID 86614846HCID 86614846, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 500 mg (2.66 mmol) of 2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrazine (Intermediate 7, Step C) in 2.5 mL of dry ethanol, stirred at 0° C. under protection from moisture, was treated dropwise with 0.151 mL (2.92 mmol) of bromine. After 20 minutes at 0° C., the solution was concentrated and dried to give the title compound as an orange solid. LC-MS 267, 269 (M+1).

Workup

  1. concentrationthe solution was concentrated
  2. customdried

Sources & evidence

ORD record
ord-e48a2703268745d3974240685fe84e94
Source dataset
uspto-grants-2009_12
Patent number
US07625888B2

Reaction notes

Loading…