1-Hydroxybenzotriazole → HCID 178495997, compound

Participants

Reaction Steps

A mixture of 500 mg (2.78 mmol) of 3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid, 0.333 mL (3.05 mmol) of aminoacetaldehyde dimethyl acetal, 588 mg (3.05 mmol) of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC), 510 mg (3.33 mmol) of 1-hydroxybenzotriazole (HOBT), 1.92 mL (11.1 mmol) of N,N-diisopropylethylamine, and 20 mL of dichloromethane was stirred at room temperature for 20 h and then concentrated. Purification of the residue by flash chromatography on silica gel (0-10% methanol in dichloromethane) afforded the title compound as a white solid. LC-MS 268 (M+1).

Provenance & Evidence