HCID 91124768, compound → HCID 90695481, compound

Participants

Reaction Steps

A mixture of 63 mg (0.115 mmol) of tert-butyl((1R)-3-oxo-1-(2,4,5-trifluorobenzyl)-3-{2-[2-(trifluoromethyl)-5,6-dihydropyrido[3,4-d]pyrimidin-8-yl]hydrazino}propyl)carbamate and 2 mL of 2-methoxyethanol was stirred at reflux for 5.5 h and then concentrated. Purification of the residue by preparative HPLC (C18 reverse phase column, 30-80% acetonitrile in water containing 0.05% trifluoroacetic acid) afforded the title compound as a white solid. LC-MS 529 (M+1).

Provenance & Evidence