Tert-butyl[(1r)-1-(2,5-difluorobenzyl)-3-(2-isoquinolin-1-ylhydrazino)-3-oxopropyl]carbamate → Tert-butyl[(1r)-1-(2,5-difluorobenzyl)-2-[1,2,4]triazolo[3,4-a]isoquinolin-3-ylethyl]carbamate

Participants

Reaction Steps

The crude residue from Step A was treated with 5 mL of 2-methoxyethanol, and the mixture was stirred at reflux for 1 h. The residue obtained upon concentration was flash chromatographed on silica gel (1-2.5% methanol in dichloromethane) to provide the title compound as a light tan solid, mp 185-187° C. (decomposition). LC-MS 439 (M+1).

Provenance & Evidence