HCID 57973779, compound → HCID 91433405, compound

Participants

Reaction Steps

A mixture of 129 mg (0.475 mmol) of tert-butyl[(1R)-3-hydrazino-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamate (Intermediate 4), 129 mg (0.583 mmol) of 2-(trifluoromethyl)-6,7-dihydroimidazo[1,2-a]pyrazine-8(5H)-thione (Intermediate 11), and 8.5 mL of 2-methoxyethanol was stirred at reflux for 3 days. The cooled solution was concentrated, and the residue was purified by preparative HPLC (C18 reverse phase column, 20-90% acetonitrile in water containing 0.05% trifluoroacetic acid) to give the title compound as an oil. LC-MS 517 (M+1).

Provenance & Evidence