HCID 86614853, compound → HCID 86614852, compound

Participants

Reaction Steps

A mixture of 52.1 mg (0.114 mmol) of N-{(1R)-1-(2,4,5-trifluorobenzyl)-2-[8-(trifluoromethyl)bis[1,2,4]triazolo[1,5-c:4′,3′-a]pyrimidin-3-yl]ethyl}acetamide, 52 mg of 10% palladium on carbon, and 5 mL of 2-methoxyethanol was shaken with hydrogen (52 psi) for 26 h. The catalyst was removed by filtration through Celite, and the filtrate was concentrated to dryness. The residue was purified by preparative thin-layer chromatography on silica gel (three successive developments in 92.5:7.5 dichloromethane:methanol) to provide the title compound. LC-MS 460 (M+1).

Provenance & Evidence