Ammonia → 6-Morpholinopyridine-3-sulfonamide

HRID 1863984Notes

Reaction equation

HRID 1863984 reaction equation
[N:1]1([C:7]2[N:12]=[CH:11][C:10]([S:13](Cl)(=[O:15])=[O:14])=[CH:9][CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[NH3:17]>O1CCOCC1>[N:1]1([C:7]2[N:12]=[CH:11][C:10]([S:13]([NH2:17])(=[O:15])=[O:14])=[CH:9][CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 27764626-Morpholin-4-yl-pyridine-3-sulfonyl chloride

Product 1

HCID 573002496-Morpholinopyridine-3-sulfonamideYield 96%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

6-Morpholin-4-yl-pyridine-3-sulfonyl chloride (1.25 g, 4.8 mmol) was dissolved in a 0.5M solution of ammonia in dioxane (20 mL) and the mixture stirred for 16 hours at room temperature. The mixture was filtered and concentrated in vacuo to afford 6-morpholin-4-yl-pyridine-3-sulfonic acid amide as a white solid 1.1 g (96% yield).

Workup

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-9d78d929518d4946b55629e785705b2b
Source dataset
uspto-grants-2009_12
Patent number
US07625896B2

Reaction notes

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