Water → HCID 920114, compound

Participants

Reaction Steps

To a stirred solution of lithium aluminum hydride (10.5 ml of 1M solution in THF, 10.5 mmol) in ether (15 mL) at 20° C. was added dropwise a solution of 1,1-dimethylethyl (3S)-3-(hydroxymethyl)-1-piperidinecarboxylate (1.50 g, 7.0 mmol) in THF (5 mL). After 1.5 h at room temperature, water (0.4 mL) was added followed by 15% aqueous sodium hydroxide solution (0.4 mL) then water (1.2 mL). This was stirred 20 min then filtered. The filtrate was concentrated under reduced pressure to give 0.87 g used in the next step without further purification. MS (ES+) m/z 130.2 (M+H)+.

Provenance & Evidence