HCID 178420353, compound → HCID 178511580, compound

HRID 1864016Notes

Reaction equation

HRID 1864016 reaction equation
C([N:8](CC1C=CC=CC=1)[C@H:9]1[CH2:14][CH2:13][C@H:12]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)[CH2:11][CH2:10]1)C1C=CC=CC=1>CO.[Pd]>[O:18]1[CH2:17][CH2:16][N:15]([C@H:12]2[CH2:11][CH2:10][C@H:9]([NH2:8])[CH2:14][CH2:13]2)[CH2:20][CH2:19]1

Participants

4

Reactant 1

HCID 178420353HCID 178420353, compound

Product 1

HCID 178511580HCID 178511580, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

7.2 g (16.4 mmol) trans-dibenzyl-4-morpholino-cyclohexylamine were dissolved in 100 mL methanol and hydrogenated on 1.4 g Pd/C (10%) at 30-50° C. The solvent was eliminated in vacuo and the residue was crystallised from ethanol and conc. hydrochloric acid.

Workup

  1. customthe residue was crystallised from ethanol and conc. hydrochloric acid

Sources & evidence

ORD record
ord-e4384cbf8c9a490ba42c5f2c1a12c5ab
Source dataset
uspto-grants-2009_12
Patent number
US07625899B2

Reaction notes

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