1-Benzyl-1H-pyrazole-4-boronic acid → HCID 131727802, compound

HRID 1864022Notes

Reaction equation

HRID 1864022 reaction equation
[C:1]([N:4]1[C:8]2=[CH:9][CH:10]=[C:11](I)[C:12](=[O:13])[N:7]2[C@H:6]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)[C@@H:5]1[C:22]1[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=1)(=[O:3])[CH3:2].[CH2:29]([N:36]1[CH:40]=[C:39](B(O)O)[CH:38]=[N:37]1)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>>[C:1]([N:4]1[C:8]2=[CH:9][CH:10]=[C:11]([C:39]3[CH:38]=[N:37][N:36]([CH2:29][C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)[CH:40]=3)[C:12](=[O:13])[N:7]2[C@H:6]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)[C@@H:5]1[C:22]1[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 33528811-Benzyl-1H-pyrazole-4-boronic acidHCID 131727799HCID 131727799, compound

Product 1

HCID 131727802HCID 131727802, compound

Procedure

rac-cis-1-Acetyl-6-(1-benzyl-1H-pyrazol-4-yl)-2,3-bis-(4-chloro-phenyl)-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one was prepared according to general method D by reaction of rac-cis-1-acetyl-2,3-bis-(4-chloro-phenyl)-2,3-dihydro-6-iodo-1H-imidazo[1,2-a]pyridin-5-one with 1-benzyl-1H-pyrazole-4-boronic acid. The compound was isolated by preparative HPLC. The expected product was characterized by LC/MS (M+H) where the mass was observed as 555.17; the expected mass is 554.1. LC/MS indicated a purity of 100% as measured by UV 214 nM.

Workup

  1. customThe compound was isolated by preparative HPLC

Sources & evidence

ORD record
ord-64a7d4ee9f134af39682c180ffa278f1
Source dataset
uspto-grants-2009_12
Patent number
US07625895B2

Reaction notes

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