3-(Methylsulfonyl)phenylboronic acid → HCID 131727803, compound

HRID 1864023Notes

Reaction equation

HRID 1864023 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[C@@H:18]([C:19]3[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=3)[N:11]3[C:12](=[O:17])[C:13](I)=[CH:14][CH:15]=[C:10]3[N:9]2[S:26]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[F:35])(=[O:28])=[O:27])=[CH:4][CH:3]=1.[CH3:36][S:37]([C:40]1[CH:41]=[C:42](B(O)O)[CH:43]=[CH:44][CH:45]=1)(=[O:39])=[O:38]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[C@@H:18]([C:19]3[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=3)[N:11]3[C:12](=[O:17])[C:13]([C:44]4[CH:43]=[CH:42][CH:41]=[C:40]([S:37]([CH3:36])(=[O:39])=[O:38])[CH:45]=4)=[CH:14][CH:15]=[C:10]3[N:9]2[S:26]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[F:35])(=[O:28])=[O:27])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27735423-(Methylsulfonyl)phenylboronic acidHCID 131727804HCID 131727804, compound

Product 1

HCID 131727803HCID 131727803, compound

Procedure

rac-cis-2,3-Bis-(4-chloro-phenyl)-1-(2-fluoro-benzenesulfonyl)-6-(3-methanesulfonyl-phenyl)-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one was prepared according to general method D by reaction of rac-cis-2,3-bis-(4-chloro-phenyl)-1-(2-fluoro-benzenesulfonyl)-2,3-dihydro-6-iodo-1H-imidazo[1,2-a]pyridin-5-one with 3-(methylsulfonyl)phenylboronic acid. The compound was isolated by preparative HPLC. The expected product was characterized by LC/MS (M+H) where the mass was observed as 669.0; the expected mass is 668. LC/MS indicated a purity of 100% as measured by UV 214 nM.

Workup

  1. customThe compound was isolated by preparative HPLC

Sources & evidence

ORD record
ord-bed06fcc33d84ab98beb1bd59254e6fd
Source dataset
uspto-grants-2009_12
Patent number
US07625895B2

Reaction notes

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