1-Acetylpiperazine → HCID 131727809, compound

HRID 1864027Notes

Reaction equation

HRID 1864027 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[C@@H:19]([C:20]3[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=3)[N:11]3[C:12](=[O:18])[C:13]([CH:16]=O)=[CH:14][CH:15]=[C:10]3[N:9]2[S:27]([C:30]2[CH:31]=[C:32]([CH:35]=[CH:36][CH:37]=2)[C:33]#[N:34])(=[O:29])=[O:28])=[CH:4][CH:3]=1.[C:38]([N:41]1[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]1)(=[O:40])[CH3:39]>>[C:38]([N:41]1[CH2:46][CH2:45][N:44]([CH2:16][C:13]2[C:12](=[O:18])[N:11]3[C@H:19]([C:20]4[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=4)[C@H:8]([C:5]4[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=4)[N:9]([S:27]([C:30]4[CH:31]=[C:32]([CH:35]=[CH:36][CH:37]=4)[C:33]#[N:34])(=[O:29])=[O:28])[C:10]3=[CH:15][CH:14]=2)[CH2:43][CH2:42]1)(=[O:40])[CH3:39]

Participants

3

Reactant 2

HCID 837951-AcetylpiperazineHCID 131727808HCID 131727808, compound

Product 1

HCID 131727809HCID 131727809, compound

Procedure

rac-3-[cis-6-(4-Acetyl-piperazin-1-ylmethyl)-2,3-bis-(4-chloro-phenyl)-5-oxo-2,3-dihydro-5H-imidazo[1,2-a]pyridine-1-sulfonyl]-benzonitrile was prepared according to general method E by reaction of rac-3-[cis-2,3-bis-(4-chloro-phenyl)-6-formyl-5-oxo-2,3-dihydro-5H-imidazo[1 2-a]pyridine-1-sulfonyl]-benzonitrile with N-acetyl-piperazine. The compound was isolated by preparative HPLC. The expected product was characterized by LC/MS (M+H) where the mass was observed as 662.12; the expected mass is 661. LC/MS indicated a purity of 100% as measured by UV 214 nM.

Workup

  1. customThe compound was isolated by preparative HPLC

Sources & evidence

ORD record
ord-0b614eec1ab54499965731b96a365c2e
Source dataset
uspto-grants-2009_12
Patent number
US07625895B2

Reaction notes

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