Succinic anhydride → HCID 60699549, compound

Participants

Reaction Steps

A solution of 5.0 g (26.5 mmol) of 1-(3-(trifluoromethyl)phenyl)ethylamine in ether (6 ml) was added dropwise in the course of 30 min to a suspension of 2.33 g (23.3 mmol) of succinic anhydride in ether (28 ml). Stirring was then carried out for 72 h at RT. The resulting precipitate was filtered off with suction and dried for 1 h in vacuo at 40° C. CC (EA/MeOH 1:4) of the residue yielded 3.68 g (12.7 mmol, 55%) of 4-oxo-4-(1-(3-(trifluoromethyl)phenyl)ethylamino)butanoic acid (S2).

Provenance & Evidence