Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-(Pyrrolidin-1-ylmethyl)aniline | HCID 1096407 | — |
| Reactant | 2-[(2,5-Dichloropyrimidin-4-yl)amino]benzamide | HCID 57974176 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 25001867 | HCID 25001867 | 70.1% |
Reaction Steps
2-[(2,5-Dichloro-4-pyrimidinyl)amino]benzamide (200 mg, 0.6 mmol) and 3-(1-pyrrolidinylmethyl)aniline (134mg, 0.75 mmol) were combined in a vessel with 5 mL isopropanol and 2 drops of 12N HCl. The vessel was sealed and heated with stirring at 95° C. for 18 h. The reaction was cooled to room temperature and the solid was filtered off and washed with isopropanol to give 178 mg (65% yield) of an orange solid as the HCl salt. MS: M(C22H23ClN6O)=422.92, (M+H)+=423 and 425.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07625903B2 |
|---|
| Source dataset | uspto-grants-2009_12 |
|---|
| ORD ID | ord-e44f2a2b90464bf1ab258b3ff7bb9865 |
|---|
| Source note | uspto-grants-2009_12 |
|---|
