Isopropylamine → 2-Amino-N-isopropylbenzamide

HRID 1864038Notes

Reaction equation

HRID 1864038 reaction equation
[C:1]12[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=1)[NH:6]C(=O)[O:4][C:2]2=O.[CH:13]([NH2:16])([CH3:15])[CH3:14]>O>[NH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:1]=1[C:2]([NH:16][CH:13]([CH3:15])[CH3:14])=[O:4]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 8359Isatoic Anhydride

Product 1

HCID 944112-Amino-N-isopropylbenzamideYield 77.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A round-bottomed flask was charged with isatoic anhydride (5.0 g, 0.030 mol) and 30 mL water. Isopropylamine (4.64 mL, 0.049 mol) was added slowly to the reaction mixture. The product precipitated from the reaction mixture. After 1 h, the reaction mixture was filtered and washed with water to give 4.12 g (71% yield) of a white solid

Workup

  1. customThe product precipitated from the reaction mixture
  2. filtrationthe reaction mixture was filtered
  3. washwashed with water

Sources & evidence

ORD record
ord-241457121dae4423992078c2dad292f4
Source dataset
uspto-grants-2009_12
Patent number
US07625903B2

Reaction notes

Loading…