3-(Pyrrolidin-1-ylmethyl)aniline → HCID 57974163, compound

HRID 1864059Notes

Reaction equation

HRID 1864059 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:11][C:12]2[C:17]([Cl:18])=[CH:16][N:15]=[C:14](Cl)[N:13]=2)=[C:6]([CH:10]=1)[C:7]([NH2:9])=[O:8].[N:20]1([CH2:25][C:26]2[CH:27]=[C:28]([CH:30]=[CH:31][CH:32]=2)[NH2:29])[CH2:24][CH2:23][CH2:22][CH2:21]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:11][C:12]2[C:17]([Cl:18])=[CH:16][N:15]=[C:14]([NH:29][C:28]3[CH:30]=[CH:31][CH:32]=[C:26]([CH2:25][N:20]4[CH2:21][CH2:22][CH2:23][CH2:24]4)[CH:27]=3)[N:13]=2)=[C:6]([CH:10]=1)[C:7]([NH2:9])=[O:8]

Participants

3

Reactant 2

HCID 10964073-(Pyrrolidin-1-ylmethyl)anilineHCID 579741905-Bromo-2-[(2,5-dichloro-4-pyrimidinyl)amino]benzamide2×

Product 1

HCID 57974163HCID 57974163, compound

Procedure

5-Bromo-2-[(5-chloro-2-{[3-(1-pyrrolidinylmethyl)phenyl]amino}-4-pyrimidinyl)amino]benzamide was prepared by contacting 5-bromo-2-[(2,5-dichloro-4-pyrimidinyl)amino]benzamide (Intermediate 37) with 3-pyrrolidinylmethylaniline following a procedure substantially as described for the preparation of Example 1. Mass (M+H)+501, 503, 505

Workup

  1. customas described for the preparation of Example 1

Sources & evidence

ORD record
ord-1eb54f9193a34d1188838e4dbe8e171a
Source dataset
uspto-grants-2009_12
Patent number
US07625903B2

Reaction notes

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