Acetyl chloride → HCID 11202933, compound

Participants

Reaction Steps

The procedure described in Example 5 was repeated using N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-[2-(propylamino)ethoxy]quinazolin-4-amine and acetyl chloride to give the title compound in 70% yield; NMR spectrum (DMSO-d6) 0.82 (t, 3H), 1.53-1.59 (m, 2H), 1.97 (s, 3H), 3.27 (s, 2H), 3.86 (t, 2H), 4.39 (t, 2H), 5.31 (s, 2H), 7.17 (d, 1H), 7.25 (d, 1H), 7.33-7.39 (m, 2H), 7.58-7.60 (m, 2H), 7.71-7.75 (m, 1H), 7.87-7.91 (m, 1H), 7.95 (d, 1H), 8.45 (s, 1H), 8.60 (d, 1H), 9.80 (s, 1H); Mass spectrum MH+ 506.

Provenance & Evidence