Glycolic Acid → HCID 11752756, compound

Participants

Reaction Steps

The procedure described in Example 1 was repeated using glycolic acid and N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-[2-(propylamino)ethoxy]quinazolin-4-amine (obtained as described in Example 7, preparation of starting materials) to give the title compound in 26% yield; NMR spectrum (DMSO-d6) 0.84 (t, 3H), 1.53-1.65 (m, 2H), 3.26 (t, 2H), 3.95 (t, 2H), 4.14 (d, 2H), 4.38 (t, 1H), 4.47 (t, 2H), 4.53-4.58 (m, 1H), 5.36 (s, 1H), 7.24 (d, 1H), 7.31 (d, 1H), 7.39-7.44 (m, 2H), 7.63-7.67 (m, 2H), 7.76-7.81 (m, 1H), 7.92-7.96 (m, 1H), 8.05 (s, 1H), 8.51 (s, 1H), 8.66 (d, 1H), 9.87 (s, 1H); Mass spectrum MH+ 522.

Provenance & Evidence