Acetyl chloride → HCID 57974327, compound

Participants

Reaction Steps

The procedure described in Example 5 was repeated using N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-[2-(isopropylamino)ethoxy]quinazolin-4-amine and acetyl chloride to give the title compound in 49% yield; NMR spectrum (DMSO-d6) 1.19 (d, 6H), 2.07 (s, 3H), 3.77 (t, 2H), 4.06-4.14 (m, 1H), 4.34 (t, 2H), 5.31 (s, 2H), 7.21 (d, 1H), 7.27 (d, 1H), 7.32-7.39 (m, 2H), 7.57-7.63 (m, 2H), 7.69-7.75 (m, 1H), 7.86-7.91 (m, 1H), 8.01 (d, 1H), 8.46 (s, 1H), 8.60 (d, 1H), 10.00 (s, 1H); Mass spectrum MH+ 506.

Provenance & Evidence