Glycolic Acid → HCID 11386865, compound

Participants

Reaction Steps

The procedure described in Example 1 was repeated using glycolic acid and N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-[2-(isopropylamino)ethoxy]quinazolin-4-amine (obtained as described in Example 9, preparation of starting materials) to give the title compound in 11% yield; NMR spectrum (DMSO-d6) 1.19 (d, 6H), 3.81 (t, 2H), 3.93-4.01 (m, 1H), 4.14-4.18 (m, 2H), 4.35-4.47 (m, 3H), 5.31 (s, 2H), 7.21-7.29 (m, 2H), 7.32-7.40 (m, 2H), 7.56-7.63 (m, 2H), 7.70-7.76 (m, 1H), 7.86-7.91 (m, 1H), 8.04 (s, 1H), 8.47 (s, 1H), 8.60 (d, 1H), 10.02 (s, 1H); Mass spectrum MH+ 522.

Provenance & Evidence