Acetyl chloride → HCID 57974339, compound

Participants

Reaction Steps

The procedure described in Example 5 was repeated using 5-[2-(allylamino)ethoxy]-N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]quinazolin-4-amine and acetyl chloride to give the title compound in 47% yield; NMR spectrum (DMSO-d6) 1.95 (s, 3H), 3.86 (t, 2H), 4.02-4.06 (m, 2H), 4.38 (t, 2H), 5.07-5.18 (m, 2H), 5.31 (s, 2H), 5.82-5.92 (m, 1H), 7.14 (d, 1H), 7.25 (d, 1H), 7.32-7.40 (m, 2H), 7.55-7.61 (m, 2H), 7.70-7.75 (m, 1H), 7.86-7.93 (m, 2H), 8.44 (s, 1H), 8.61 (d, 1H), 9.76 (s, 1H); Mass spectrum MH+ 504.

Provenance & Evidence