Glycolic Acid → HCID 11477908, compound

Participants

Reaction Steps

The procedure described in Example 1 was repeated using glycolic acid and N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-[2-(cyclopropylamino)ethoxy]quinazolin-4-amine (obtained as described in Example 13, preparation of starting materials) to give the title compound in 19% yield; NMR spectrum (DMSO-d6) 0.73-0.80 (m, 4H), 2.73-2.80 (m, 1H), 3.90 (t, 2H), 4.24 (s, 3H), 4.44 (t, 2H), 5.31 (s, 2H), 7.20 (d, 1H), 7.25 (d, 1H), 7.35 (d, 1H), 7.36-7.40 (m, 1H), 7.57-7.62 (m, 2H), 7.71-7.76 (m, 1H), 7.86-7.92 (m, 1H), 8.01 (d, 1H), 8.46 (s, 1H), 8.61 (d, 1H), 9.80 (s, 1H); Mass spectrum MH+ 520.

Provenance & Evidence