Glycolic Acid → HCID 11432600, compound

Participants

Reaction Steps

The procedure described in Example 1 was repeated using glycolic acid and N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-{2-[(cyclopropylmethyl)amino]ethoxy}quinazolin-4-amine (obtained as described in Example 15, preparation of starting materials) to give the title compound in 23% yield; NMR spectrum (DMSO-d6)-0.04-0.04 (m, 2H), 0.13-0.29 (m, 2H), 0.74-0.83 (m, 1H), 2.98 (d, 1H), 3.66-3.80 (m, 2H), 3.85-3.93 (m, 2H), 4.12-4.32 (m, 4H), 5.08 (s, 2H), 6.95 (d, 1H), 7.02 (d, 1H), 7.09-7.17 (m, 2H), 7.30-7.40 (m, 2H), 7.47-7.54 (m, 1H), 7.63-7.68 (m, 1H), 7.73-7.82 (m, 1H), 8.21-8.29 (m, 1H), 8.37 (d, 1H), 9.62 (s, 1H); Mass spectrum MH+ 534.

Provenance & Evidence