Glycolic Acid → HCID 57974303, compound

Participants

Reaction Steps

The procedure described in Example 1 was repeated using glycolic acid and N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-[2-(cyclobutylamino)ethoxy]quinazolin-4-amine (obtained as described in Example 17, preparation of starting materials) to give the title compound in 22% yield; NMR spectrum (DMSO-d6) 1.49-1.65 (m, 2H), 2.08-2.27 (m, 4H), 3.97 (s, 2H), 4.12 (d, 2H), 4.20-4.29 (m, 1H), 4.32-4.43 (m, 3H), 5.31 (s, 2H), 7.21 (d, 1H), 7.26 (d, 1H), 7.33-7.40 (m, 2H), 7.57-7.63 (m, 2H), 7.71-7.76 (m, 1H), 7.86-7.92 (m, 1H), 8.02 (s, 1H), 8.47 (s, 1H), 8.60 (d, 1H), 9.92 (s, 1H); Mass spectrum MH+ 534.

Provenance & Evidence